SOX7 Target Genes and Their Contribution to Its Tumor Suppressive Function
نویسندگان
چکیده
منابع مشابه
The Suppressive Role of SOX7 in Hepatocarcinogenesis
SOX7 is a transcription factor mediating various developmental processes. However, its role in hepatocellular carcinoma (HCC) remains unclear. Here, we assessed the role of SOX7 in hepatocarcinogenesis. We found HCC samples exhibited lower levels of SOX7 mRNA and protein expression than non-tumor samples, and the expression of SOX7 was negatively correlated with tumor size. SOX7 expression was ...
متن کاملSuppression of SOX7 by DNA methylation and its tumor suppressor function in acute myeloid leukemia.
SOX7 belongs to the SOX (Sry-related high-mobility group [HMG] box) gene family, a group of transcription factors containing in common a HMG box domain. Its role in hematologic malignancies and, in particular, acute myeloid leukemia (AML) is completely unknown. Here, we showed that SOX7 expression was regulated by DNA hypermethylation in AML but not in acute lymphoblastic leukemia or normal bon...
متن کاملSuppression of SOX7 by DNA methylation and its tumor suppressor function in acute myeloid leukemia. Running Title: SOX7 in acute myeloid leukemia
SOX7 belongs to the SOX (Sry-related HMG box) gene family, a group of transcription factors containing in common a High-Mobility-Group (HMG) box domain. Its role in hematological malignancies and in particular acute myeloid leukemia (AML) is completely unknown. Here we showed that SOX7 expression was regulated by DNA hypermethylation in AML but not in acute lymphoblastic leukemia (ALL) or norma...
متن کاملSOX7: from a developmental regulator to an emerging tumor suppressor.
SOX7 belongs to the SOX (SRY-related HMG-box) family of transcription factors that have been shown to regulate multiple biological processes, such as hematopoiesis, vasculogenesis and cardiogenesis during embryonic development. Recent studies indicate that several SOX family members play important roles in tumorigenesis. In this review, we introduce SOX7 gene and protein structures, and discuss...
متن کاملThe Tumor Suppressive Role of eIF3f and Its Function in Translation Inhibition and rRNA Degradation
Deregulated translation plays an important role in human cancer. We previously reported decreased eukaryotic initiation factor 3 subunit f (eIF3f) expression in pancreatic cancer. Whether decreased eIF3f expression can transform normal epithelial cells is not known. In our current study, we found evidence that stable knockdown of eIF3f in normal human pancreatic ductal epithelial cells increase...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: International Journal of Molecular Sciences
سال: 2018
ISSN: 1422-0067
DOI: 10.3390/ijms19051451